Sokoine University of Agriculture

Using giant african pouched rats to detect human tuberculosis: A review

Show simple item record Poling, A. Mahoney, A. Beyene, N. Mgode, G. Weetjens, B. Cox, C. Durgin, A. 2020-06-19T11:33:53Z 2020-06-19T11:33:53Z 2015-08-31
dc.identifier.issn 1937-8688
dc.description Pan African Medical Journal. 2015 en_US
dc.description.abstract Despite its characteristically low sensitivity, sputum smear microscopy remains the standard for diagnosing tuberculosis (TB) in resource-poor countries. In an attempt to develop an alternative or adjunct to microscopy, researchers have recently examined the ability of pouched rats to detect TB-positive human sputum samples and the microbiological variables that affect their detection. Ten published studies, reviewed herein, suggest that the rats are able to detect the specific odor of Mycobacterium tuberculosis , which causes TB, and can substantially increase new-case detections when used for second-line TB screening following microscopy. Further research is needed to ascertain the rats' ability to detect TB in children and in HIV-positive patients, to detect TB when used for first-line screening, and to be useful in broad-scale applications where cost- effectiveness is a major consideration. en_US
dc.language.iso en en_US
dc.publisher Pan African Medical Journal en_US
dc.subject Pouched rats en_US
dc.subject Human tuberculosis en_US
dc.subject Rats training en_US
dc.subject A review en_US
dc.title Using giant african pouched rats to detect human tuberculosis: A review en_US
dc.type Article en_US
dc.url en_US

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